thymoma | Reynolds syndrome reveals a malignant thymoma

Reynolds syndrome reveals a malignant thymoma

Reynolds syndrome revealing a malignant thymoma

M. Michaud A, ⁎, B, C. Gaudin b, D. Brechemier A, G. Moldis A, L. Astudillo A, v. Guillotreau C, L. Bacony b
A Department of Internal Medicine, hospital of Purpan, Chu of Toulouse, place of doctor-Bandari, TSA 40031, 31059 Toulouse, France b Gerontology Clinical and Internal Medicine, hospital of Casselardit, Chu of Toulouse, 31059 Toulouse, France c Department of Anatomy Pathological, histology and cytology, Hospital of Rangueil, CHU of Toulouse, 31059 Toulouse, France corresponding author.

Summary
Introduction
A mild or malignant thymic pathology can accompany autoimmune pathologies. If it is more frequent in the case of myasthenia gravis, Neuromyotonia or PRCA, it can be found in almost all autoimmune diseases.

Observation
We report the first description, to our knowledge, of an association between a malignant thymoma and a Reynolds syndrome (defined by the presence of primary biliary cirrhosis and scleroderma).

Conclusion
The Advanced pathophysiological hypothesis is a thymic exhaust of self-reactive T lymphocytes that cause autoimmune pathology in this context of multiple autoimmune syndrome.

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Abstract
Introduction
Thymomas, benign or malignant, may be associated with autoimmune diseases. They are classically associated with myasthenia gravis, Neuromyotonia, or pure red cell aplasia.

Case Report
We here report, to the best of our knowledge, the first description of an association between Thymoma and Reynolds syndrome (systemic sclerosis associated with primary liary cirrhosis) in an 80-year-old woman.

Conclusion
The suspected pathogenesis of this association could be a thymus escape of self-reactive T lymphocytes and the consecutive development of an auto-immune disorder.